Bayesian Continual Reassessment Method for Phase I Dose-Escalation Trials


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Documentation for package ‘bcrm’ version 0.4.6

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bcrm-package Bayesian Continual Reassessment Method for Phase I Dose-Escalation Trials
bcrm Bayesian Continual Reassessment Method for Phase I Dose-Escalation Trials
find.x Obtain samples from the maximum tolerated dose (MTD) distribution.
getprior Samples from the specified prior distribution.
plot.bcrm Plot the estimated dose-toxicity curve
plot.bcrm.sim Plot the operating characteristics from the simulated trials
plot.threep3 Plot the operating characteristics from a standard 3+3 trial
Posterior.BRugs Calculate posterior distribution of CRM model parameter(s)
Posterior.exact Calculate posterior distribution of CRM model parameter(s)
Posterior.R2WinBUGS Calculate posterior distribution of CRM model parameter(s)
Posterior.rjags Calculate posterior distribution of CRM model parameter(s)
print.bcrm Print information regarding a trial conducted using the Bayesian continuous reassessment method
print.bcrm.sim Print information regarding a trial conducted using the Bayesian continuous reassessment method
print.threep3 Print information regarding the operating characteristics of a standard 3+3 design
threep3 Calculate all possible trial pathways for the standard 3+3 design, together with their probability of occurring