Design and Analysis of Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control


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Documentation for package ‘ThreeArmedTrials’ version 1.0-0

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ThreeArmedTrials-package Design and Analysis of Three-armed Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control
check_missing check_missing
check_RET_arguments check_RET_arguments
GElesions Total number of new galodinium-enhancing lesions.
is.naturalnumber is.naturalnumber
loglikelihood_binary loglikelihood_binary
opt_alloc_RET Optimal sample size for three-arm trials when analyzed with a Wald-type test
power.taNegbin.test Power related calcuations for three-armed clinical trials with negative binomial distributed endpoints
power_RET Power related calcuations for three-arm clinical trials
remission Remission in clinical trial in patients with depression.
seizures Number of seizures per patient.
T2lesions Number of new and enlarging T2 lesions per patient.
taNegBin.OptAllocation Optimal sample size for three-armed clinical trials with negative binomial distributed endpoints
taNegbin.test Statistical test for three-armed clinical trials with negative binomial distributed endpoints.
test_RET Wald-type test for three-arm trials
ThreeArmedTrials Design and Analysis of Three-armed Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control