cohort | Cohort numbers of evaluated patients. |
continue | Should this dose-finding experiment continue? |
demand_n_at_dose | Demand there are n patients at a dose before condisdering stopping. |
dont_skip_doses | Prevent skipping of doses. |
doses_given | Doses given to patients. |
dose_indices | Dose indices |
empiric_tox_rate | Observed toxicity rate at each dose. |
enforce_three_plus_three | Enforce that a trial path has followed the 3+3 method. |
fit | Fit a dose-finding model. |
follow_path | Follow a pre-determined dose administration path. |
get_boin | Get an object to fit the BOIN model using the BOIN package. |
get_dfcrm | Get an object to fit the CRM model using the dfcrm package. |
get_three_plus_three | Get an object to fit the 3+3 model. |
mean_prob_tox | Mean toxicity rate at each dose. |
median_prob_tox | Median toxicity rate at each dose. |
model_frame | Model data-frame. |
num_doses | Number of doses. |
num_patients | Number of patients evaluated. |
num_tox | Total number of toxicities seen. |
n_at_dose | Number of patients treated at each dose. |
parse_phase1_outcomes | Parse a string of phase I dose-finding outcomes to vector notation. |
phase1_outcomes_to_cohorts | Break a phase I outcome string into a list of cohort parts. |
prob_administer | Percentage of patients treated at each dose. |
prob_tox_exceeds | Probability that the toxicity rate exceeds some threshold. |
prob_tox_quantile | Quantile of the toxicity rate at each dose. |
prob_tox_samples | Get samples of the probability of toxicity. |
recommended_dose | Recommended dose for next patient or cohort. |
selector | Dose selector. |
selector_factory | Dose selector factory. |
select_dose_by_cibp | Select dose by the CIBP selection criterion. |
stop_at_n | Stop when there are n patients in total. |
stop_when_n_at_dose | Stop when there are n patients at a dose. |
stop_when_too_toxic | Stop when a dose is too toxic. |
stop_when_tox_ci_covered | Stop when uncertainty interval of prob tox is covered. |
supports_sampling | Does this selector support sampling of outcomes? |
three_plus_three | Fit the 3+3 model to some outcomes. |
tox | Binary toxicity outcomes. |
tox_at_dose | Number of toxicities seen at each dose. |
tox_target | Target toxicity rate |