The Pharmacokinetics (PK) of Multi-Component Drugs Using a Metabolomics Approach


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Documentation for package ‘polyPK’ version 3.1.0

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A Test data of differential metabolites
B Test data of endogenous metabolites
C Test data of absorbed drug metabolites
CorrPlot Plot the correlation diagram of two datasets
DataPre Preprocess the input data
design Test data of study design
drugData The drug constitutes dataset (data frame)
GetAbso Get the absorbed drug constitutes from the differential compounds
GetDiffData Get the differential compounds across all the time points
GetEndo Get the altered endogenous metabolites from the differential compounds
GetSecdAbso Get the secondary metabolites of the absorbed drug constitutes
HeatMap Plot the heatmap of input data
PKs Calculate the representative pharmacokinetics parameters and plot the time-intensity curves of specified compounds.
postData The post-dose metabolites dataset (data frame)
preData The pre-dose metabolites dataset (data frame)
ScatPlot Plot the PCA or PLSDA score figures and trajectories on input data
Simi Get the same compounds in two datasets
simidata Test data of same compounds.